Transcriptional changes induced by the tumor dormancy-associated microRNA-190
نویسندگان
چکیده
منابع مشابه
Transcriptional changes induced by the tumor dormancy-associated microRNA-190
Tumor dormancy is a highly prevalent stage in cancer progression. We have previously generated and characterized in vivo experimental models of human tumor dormancy in which micro-tumors remain occult until they spontaneously shift into rapid tumor growth. We showed that the dormant micro-tumors undergo a stable microRNA (miRNA) switch during their transition from dormancy to a fast-growing phe...
متن کاملMicroRNA-155, induced by FOXP3 through transcriptional repression of BRCA1, is associated with tumor initiation in human breast cancer
MicroRNA (miR)-155 is upregulated in breast cancer cells and in sera of patients with breast cancer, but its clinical relevance remains uncertain. The objective of the present effort was to address the transcriptional regulation of miR-155. A bioinformatics analysis of public datasets validated upregulation of miR-155 in tumor cells of patients with breast cancer, particularly those who were at...
متن کاملAutophagy-induced tumor dormancy in ovarian cancer.
Autophagy--a process of "self-eating" that involves enzymatic digestion and recycling of cellular constituents in response to stress--contributes to both cancer cell death and survival. In this issue of the JCI, Lu et al. report that controlled induction of tumor suppressor gene aplasia Ras homolog member I (ARHI) results in autophagic cell death of human ovarian cancer cells in vitro (see the ...
متن کاملAWARD NUMBER: W81XWH-14-1-0087 TITLE: Treatment-Induced Autophagy Associated with Tumor Dormancy and Relapse
Two major barriers to cancer immunotherapy includetumor-induced immune suppression mediated bymyeloid-derived suppressor cells and poor immunoge-nicity of the tumor-expressing self-antigens. To over-come these barriers, we reprogrammed tumor-immunecell cross-talk by combined use of decitabine andadoptive immunotherapy, containing tumor-sensitizedT cells and CD25 NKT ...
متن کاملTranscriptional mechanisms associated with seed dormancy and dormancy loss in the gibberellin-insensitive sly1-2 mutant of Arabidopsis thaliana
While widespread transcriptome changes were previously observed with seed dormancy loss, this study specifically characterized transcriptional changes associated with the increased seed dormancy and dormancy loss of the gibberellin (GA) hormone-insensitive sleepy1-2 (sly1-2) mutant. The SLY1 gene encodes the F-box subunit of an SCF E3 ubiquitin ligase needed for GA-triggered proteolysis of DELL...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Transcription
سال: 2013
ISSN: 2154-1264,2154-1272
DOI: 10.4161/trns.25558